Jonathan Coulton's "W's Duty".
source: Thing a Week 3 - W’s Duty.
This is one of the podcasts that I subscribe to in iTunes and I have been listening back to some old episodes. SO good.
He sometimes does gamer/geek parodies as well, such as "Chiron Beta Prime" (more posts here) which has been used the backing track for a WoW parody video by zeedoos as well as the more official video by jocopro of the Jonathan Coulton Project, "which is a video podcast that makes music videos for Jonathan Coulton songs".
"... where we're working in a mine for our robot overlords. Did I say overlords? I meant protectors!"
Jonathan Coulton. A genius.